It’s accessing literally anything you self host from home, with minimal latency and without any port forwarding on your router or exposing your services to the Internet.
It’s primary benefit is how fast it is, how much easier it is to set up for even the most novice of users, and how ubiquitous all the clients are.
Plus it’s free for 100 endpoints, which is far more than most individuals will need for home labs. And even that you can get around by using subnet routing.
If you’ve ever wanted to run your own sort of Dropbox or Google docs (Syncthing/Next cloud) but didn’t want to deal with the security hassle of exposing it to the Internet, this removes that completely. No more struggling with open ports, fail2ban, or messing with reverse proxies.
https://tailscale.com/kb/1218/nextdns/
Easy to set up, mine is working great.